Fluorodeoxyuridylate
id:
fluorodeoxyuridylate-315-15587062
title:
Fluorodeoxyuridylate
text:
Fluorodeoxyuridylate, also known as FdUMP, 5-fluoro-2'-deoxyuridylate, and 5-fluoro-2'-deoxyuridine 5'-monophosphate, is a molecule formed in vivo from 5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops the rapidly proliferation of fast-growing tumors, and it is therefore widely used as a cancer treatment. Fluorouracil (5-FU) performs as a substrate during part of the catalytic cycl
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Fluorodeoxyuridylate
date created:
date modified:
2024-03-30T22:59:13Z
main entity:
{"identifier":"Q27105559","url":"https://www.wikidata.org/entity/Q27105559"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/e/ec/5-Fluorodeoxyuridine_monophosphate.svg","width":715,"height":350}
fields total:
13
integrity:
15