Filibuvir
id:
filibuvir-274-13690254
title:
Filibuvir
text:
Filibuvir was a non-nucleoside orally available NS5B inhibitor developed by Pfizer for the treatment of hepatitis C. It binds to the non-catalytic Thumb II allosteric pocket of NS5B viral polymerase and causes a decrease in viral RNA synthesis. It is a potent and selective inhibitor, with a mean IC50 of 0.019 μM against genotype 1 polymerases. Several filibuvir-resistant mutations have been identified, M423 being the most common that occurred after filibuvir monotherapy. It was intended to be ta
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Filibuvir
date created:
date modified:
2023-01-22T16:27:41Z
main entity:
{"identifier":"Q24975766","url":"https://www.wikidata.org/entity/Q24975766"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/7/74/Filibuvir.svg","width":512,"height":222}
fields total:
13
integrity:
15