Evans–Saksena reduction
id:
evans-saksena-reduction-237-10141563
title:
Evans–Saksena reduction
text:
The Saksena–Evans reduction is a diastereoselective reduction of β-hydroxy ketones to the corresponding anti-dialcohols, employing the reagent tetramethylammonium triacetoxyborohydride (Me4NHB(OAc)3). The reaction was first described by Anil K. Saksena in 1983 and further developed by David A. Evans in 1987. The reaction is thought to proceed through the 6-membered ring transition state shown below. The intramolecular hydride delivery from the boron reducing agent forces the reduction to proceed
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Evans%E2%80%93Saksena_reduction
date created:
date modified:
2021-03-28T14:21:20Z
main entity:
{"identifier":"Q4371749","url":"https://www.wikidata.org/entity/Q4371749"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/4/4e/Evans-Saksena_transition_state.tif","width":624,"height":411}
fields total:
13
integrity:
14