Erastin
id:
erastin-187-16237831
title:
Erastin
text:
Erastin is a small molecule capable of initiating ferroptotic cell death. Erastin binds and activates voltage-dependent anion channels (VDAC) by reversing tubulin's inhibition on VDAC2 and VDAC3, and functionally inhibits the cystine-glutamate antiporter system Xc−. Cells treated with erastin are deprived of cysteine and are unable to synthesize the antioxidant glutathione. Depletion of glutathione eventually leads to excessive lipid peroxidation and cell death. Erastin was first described in 20
brand slug:
wiki
category slug:
encyclopedia
description:
Molecule initiating ferroptotic cell death
original url:
https://en.wikipedia.org/wiki/Erastin
date created:
2017-04-04T13:41:47Z
date modified:
2024-09-08T18:29:01Z
main entity:
{"identifier":"Q30633486","url":"https://www.wikidata.org/entity/Q30633486"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/8/80/Erastin_Structure.svg","width":1828,"height":2076}
fields total:
13
integrity:
16