EME1
id:
eme1-232-11105957
title:
EME1
text:
Crossover junction endonuclease EME1 is an enzyme that in humans is encoded by the EME1 gene. It forms a complex with MUS81 which resolves Holliday junctions. In mammalian cells the EME1/MUS81 protein complex is redundant for DNA damage repair with GEN1 endonuclease. In mice, EME1/MUS81 and GEN1 redundantly contribute to Holliday junction processing. When homozygous mutations of Gen1 and Eme1 were combined in mice the result was synthetic lethality at an early embryonic stage. Homozygosity for G
brand slug:
wiki
category slug:
encyclopedia
description:
Protein-coding gene in the species Homo sapiens
original url:
https://en.wikipedia.org/wiki/EME1
date created:
date modified:
2022-11-18T16:08:33Z
main entity:
{"identifier":"Q18051492","url":"https://www.wikidata.org/entity/Q18051492"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/6/62/Protein_EME1_PDB_2ZIU.png","width":1200,"height":1000}
fields total:
13
integrity:
15