Dihydroorotate dehydrogenase
id:
dihydroorotate-dehydrogenase-187-18613441
title:
Dihydroorotate dehydrogenase
text:
Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane (IMM). Inhibitors of this enzyme are used to treat autoimmune diseases such as rheumatoid arthritis.
brand slug:
wiki
category slug:
encyclopedia
description:
Class of enzymes
original url:
https://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase
date created:
2007-02-19T16:32:37Z
date modified:
2024-09-08T17:09:25Z
main entity:
{"identifier":"Q1150909","url":"https://www.wikidata.org/entity/Q1150909"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/8/82/6cjf.jpg","width":1000,"height":797}
fields total:
13
integrity:
16