Diflomotecan
id:
diflomotecan-290-11965420
title:
Diflomotecan
text:
Diflomotecan is a chemotherapeutic agent that is a topoisomerase inhibitor (Top1). It varies from other camptothecin based Top1 inhibitors like topotecan in having a 7-membered E-ring. The oxepan-2-one ring in the homocamptothecin analogues is more stable in plasma compared to the 6-membered lactone in camptothecin. Diflomotecan was the first homocamptothecin to enter clinical trials and is currently in phase I for treating patients with sensitive small cell lung cancer (SCLC).
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Diflomotecan
date created:
date modified:
2023-08-09T09:10:39Z
main entity:
{"identifier":"Q27287310","url":"https://www.wikidata.org/entity/Q27287310"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/1/12/Diflomotecan.png","width":840,"height":491}
fields total:
13
integrity:
15