Darier's sign
id:
darier-s-sign-259-3172032
title:
Darier's sign
text:
Darier's sign is a change observed after stroking lesions on the skin of a person with systemic mastocytosis or urticaria pigmentosa. In general, the skin becomes swollen, itchy and red. This is a result of compression of mast cells, which are hyperactive in these diseases. These mast cells release inflammatory granules which contain histamine. It is the histamine which is responsible for the response seen after rubbing the lesional skin.
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Darier%27s_sign
date created:
date modified:
2023-07-25T19:11:47Z
main entity:
{"identifier":"Q2094620","url":"https://www.wikidata.org/entity/Q2094620"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/a/a1/Stroking_of_skin_leads_to_anaphylactoid_reaction%2Cthereby_causing_localised_subcutaneous_mast_cell_degranulation_causing_eythema_and_edemtous_uticarial_manifestation%21_2013-06-06_14-44.jpg","width":90,"height":121}
fields total:
13
integrity:
14