D145E
id:
d145e-273-7383245
title:
D145E
text:
D145E is a point mutation on troponin C that leads to hypertrophic cardiomyopathy disease. This mutation is caused by the change of nucleotide C to A at nucleotide 435, switching the amino acid aspartic acid to glutamic acid, which is located at the C-terminal tail. Patients with this mutation have different structure on the thin filament and alter the binding of Ca2+ at the troponin C site IV. Further, D145E causes increase in development of force and activation of ATPase in the presence of Ca2
brand slug:
wiki
category slug:
encyclopedia
description:
Point mutation
original url:
https://en.wikipedia.org/wiki/D145E
date created:
date modified:
2021-10-03T20:06:25Z
main entity:
{"identifier":"Q97359596","url":"https://www.wikidata.org/entity/Q97359596"}
image:
fields total:
13
integrity:
14