Cyclic GMP-AMP synthase
id:
cyclic-gmp-amp-synthase-238-12307289
title:
Cyclic GMP-AMP synthase
text:
Cyclic GMP-AMP synthase, belonging to the nucleotidyltransferase family, is a cytosolic DNA sensor that activates a type-I interferon response. It is part of the cGAS-STING DNA sensing pathway. It binds to microbial DNA as well as self DNA that invades the cytoplasm, and catalyzes cGAMP synthesis. cGAMP then functions as a second messenger that binds to and activates the endoplasmic reticulum protein STING to trigger type-I IFNs production. Mice lacking cGAS are more vulnerable to lethal infecti
brand slug:
wiki
category slug:
encyclopedia
description:
Cytosolic DNA sensor
original url:
https://en.wikipedia.org/wiki/Cyclic_GMP-AMP_synthase
date created:
date modified:
2024-01-23T18:35:21Z
main entity:
{"identifier":"Q108841452","url":"https://www.wikidata.org/entity/Q108841452"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/d/d3/CGAS_complexed_with_dsDNA.png","width":1200,"height":913}
fields total:
13
integrity:
15