CFTR inhibitory factor
id:
cftr-inhibitory-factor-232-8938784
title:
CFTR inhibitory factor
text:
The CFTR inhibitory factor (Cif) is a protein virulence factor secreted by the Gram-negative bacteria Pseudomonas aeruginosa and Acinetobacter nosocomialis. Discovered at Dartmouth Medical School, Cif is able to alter the trafficking of select ABC transporters in eukaryotic epithelial cells, such as the cystic fibrosis transmembrane conductance regulator (CFTR), and P-glycoprotein by interfering with the host deubiquitinating machinery. By promoting the ubiquitin-mediated degradation of CFTR, Ci
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/CFTR_inhibitory_factor
date created:
date modified:
2023-10-11T23:49:11Z
main entity:
{"identifier":"Q5010864","url":"https://www.wikidata.org/entity/Q5010864"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/f/f5/Cif.dimer_1.png","width":2400,"height":1440}
fields total:
13
integrity:
14