Casiraghi formylation
id:
casiraghi-formylation-196-2794627
title:
Casiraghi formylation
text:
In organic synthesis, the Casiraghi formylation is the formation of a salicylaldehyde from a phenol and paraformaldehyde. The reaction requires a strong Brønsted base and a weak Lewis acid, and gives a methanol coproduct: Formally, it combines the Cannizzaro disproportionation with a directed Friedel-Crafts acylation. In Casiraghi's original 1978 formulation, Grignard reagents served as both the hindered base and Lewis acid. Applications include the synthesis of tocopherol derivatives.
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Casiraghi_formylation
date created:
date modified:
2024-01-05T21:51:35Z
main entity:
{"identifier":"Q123481390","url":"https://www.wikidata.org/entity/Q123481390"}
image:
fields total:
13
integrity:
13