Canertinib
id:
canertinib-280-9690537
title:
Canertinib
text:
Canertinib (CI-1033) is an experimental drug candidate for the treatment of cancer. It is an irreversible tyrosine-kinase inhibitor with activity against EGFR (IC50 0.8 nM), HER-2 (IC50 19 nM) and ErbB-4 (IC50 7 nM). By 2015, Pfizer had discontinued development of the drug. Canertinib has been reported as a substrate for the transporter protein OATP1B3. Interaction of canertinib with OATP1B3 may alter its hepatic disposition and can lead to transporter mediated drug-drug interactions. Canertinib
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Canertinib
date created:
date modified:
2024-04-07T19:23:03Z
main entity:
{"identifier":"Q5032274","url":"https://www.wikidata.org/entity/Q5032274"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/3/30/Canertinib.svg","width":512,"height":284}
fields total:
13
integrity:
15