Bump and hole
id:
bump-and-hole-203-1902512
title:
Bump and hole
text:
The bump-and-hole method is a tool in chemical genetics for studying a specific isoform in a protein family without perturbing the other members of the family. The unattainability of isoform-selective inhibition due to structural homology in protein families is a major challenge of chemical genetics. With the bump-and-hole approach, a protein–ligand interface is engineered to achieve selectivity through steric complementarity while maintaining biochemical competence and orthogonality to the wild
brand slug:
wiki
category slug:
encyclopedia
description:
Tool in chemical genetics
original url:
https://en.wikipedia.org/wiki/Bump_and_hole
date created:
date modified:
2024-03-18T19:34:02Z
main entity:
{"identifier":"Q96374110","url":"https://www.wikidata.org/entity/Q96374110"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/7/7f/Bump-and-hole_engineering.png","width":524,"height":314}
fields total:
13
integrity:
15