Blaise reaction
id:
blaise-reaction-193-2889856
title:
Blaise reaction
text:
The Blaise reaction is an organic reaction that forms a β-ketoester from the reaction of zinc metal with a α-bromoester and a nitrile. The reaction was first reported by Edmond Blaise (1872–1939) in 1901. The final intermediate is a metaloimine, which is then hydrolyzed to give the desired β-ketoester. Bulky aliphatic esters tend to give higher yields. Steven Hannick and Yoshito Kishi have developed an improved procedure. It has been noted that free hydroxyl groups can be tolerated in the course
brand slug:
wiki
category slug:
encyclopedia
description:
original url:
https://en.wikipedia.org/wiki/Blaise_reaction
date created:
date modified:
2023-10-26T18:29:07Z
main entity:
{"identifier":"Q1992165","url":"https://www.wikidata.org/entity/Q1992165"}
image:
fields total:
13
integrity:
13