Bernthsen acridine synthesis

id: bernthsen-acridine-synthesis-191-11520542
title: Bernthsen acridine synthesis
text: The Bernthsen acridine synthesis is the chemical reaction of a diarylamine heated with a carboxylic acid and zinc chloride to form a 9-substituted acridine. Using zinc chloride, one must heat the reaction to 200-270 °C for 24hrs. The use of polyphosphoric acid will give acridine products at a lower temperature, but also with decreased yields.
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original url: https://en.wikipedia.org/wiki/Bernthsen_acridine_synthesis
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date modified: 2022-10-27T19:26:03Z
main entity: {"identifier":"Q1058157","url":"https://www.wikidata.org/entity/Q1058157"}
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