Aphidicolin
id:
aphidicolin-277-10137166
title:
Aphidicolin
text:
Aphidicolin is a tetracyclic diterpene antibiotic isolated from the fungus Cephalosporum aphidicola with antiviral and antimitotic properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase. It is a specific inhibitor of DNA polymerase Alpha and Delta in eukaryotic cells and in some viruses and an apoptosis inducer in HeLa cells. Natural aphidicolin is a secondary metabolite of the fungus Nigrospora oryzae.
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Aphidicolin
date created:
date modified:
2022-12-23T08:22:23Z
main entity:
{"identifier":"Q414000","url":"https://www.wikidata.org/entity/Q414000"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/9/95/Aphidicolin_structure.png","width":624,"height":330}
fields total:
13
integrity:
15