Androgen deprivation-induced senescence
id:
androgen-deprivation-induced-senescence-191-10966537
title:
Androgen deprivation-induced senescence
text:
Androgen deprivation-induced senescence refers to the induction of cellular senescence as a result of androgen deprivation therapy.
ADIS is observed in prostate cancer cells that are dependent on androgens for cell proliferation. Androgen withdrawal induces cells to undergo cellular senescence by up-regulating intracellular reactive oxygen species (ROS) that cause DNA damage. ADIS is maintained through the up-regulation of the cell cycle regulator p16ink4a.
brand slug:
wiki
category slug:
encyclopedia
description:
Medical condition
original url:
https://en.wikipedia.org/wiki/Androgen_deprivation-induced_senescence
date created:
date modified:
2024-03-11T22:01:53Z
main entity:
{"identifier":"Q16154200","url":"https://www.wikidata.org/entity/Q16154200"}
image:
fields total:
13
integrity:
14