AM-1221
id:
am-1221-276-4986316
title:
AM-1221
text:
AM-1221 is a drug that acts as a potent and selective agonist for the cannabinoid receptor CB2, with a Ki of 0.28 nM at CB2 and 52.3 nM at the CB1 receptor, giving it around 180 times selectivity for CB2. The 2-methyl and 6-nitro groups on the indole ring both tend to increase CB2 affinity while generally reducing affinity at CB1, explaining the high CB2 selectivity of AM-1221. However, despite this relatively high selectivity for CB2, its CB1 affinity is still too strong to make it useful as a
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/AM-1221
date created:
date modified:
2024-02-08T21:42:49Z
main entity:
{"identifier":"Q4652482","url":"https://www.wikidata.org/entity/Q4652482"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/7/70/AM-1221_structure.png","width":456,"height":498}
fields total:
13
integrity:
15