Alvocidib
id:
alvocidib-261-5798657
title:
Alvocidib
text:
Alvocidib is a flavonoid alkaloid CDK9 kinase inhibitor under clinical development by Tolero Pharmaceuticals for the treatment of acute myeloid leukemia. It has been studied also for the treatment of arthritis and atherosclerotic plaque formation. The target of alvocidib is the positive transcription elongation factor P-TEFb. Treatment of cells with alvocidib leads to inhibition of P-TEFb and the loss of mRNA production. The compound is a synthetic analog of natural product rohitukine which was
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/Alvocidib
date created:
date modified:
2023-11-04T23:26:59Z
main entity:
{"identifier":"Q4063441","url":"https://www.wikidata.org/entity/Q4063441"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/9/9e/Flavopiridol.svg","width":625,"height":609}
fields total:
13
integrity:
15