AI-10-49
id:
ai-10-49-285-9457326
title:
AI-10-49
text:
AI-10-49 is a small molecule inhibitor of leukemic oncoprotein CBFβ-SMHHC developed by the laboratory of John Bushweller with efficacy demonstrated by the laboratories of Lucio H. Castilla and Monica Guzman. AI-10-49 allosterically binds to CBFβ-SMMHC and disrupts protein-protein interaction between CBFβ-SMMHC and tumor suppressor RUNX1. This inhibitor is under development as an anti-leukemic drug.
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/AI-10-49
date created:
date modified:
2023-11-20T18:58:43Z
main entity:
{"identifier":"Q25111328","url":"https://www.wikidata.org/entity/Q25111328"}
image:
fields total:
13
integrity:
14