ABT-737
id:
abt-737-185-7590209
title:
ABT-737
text:
ABT-737 is a small molecule drug that inhibits Bcl-2 and Bcl-xL, two members of the Bcl-2 family of evolutionarily-conserved proteins that share Bcl-2 Homology (BH) domains. First developed as a potential cancer chemotherapy, it was subsequently identified as a senolytic. The Bcl-2 family is most notable for their regulation of apoptosis, a form of programmed cell death, at the mitochondrion; Bcl-2 and Bcl-xL are anti-apoptotic proteins. Because many cancers have mutations in these genes that al
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/ABT-737
date created:
2016-05-03T01:39:17Z
date modified:
2024-09-07T19:46:03Z
main entity:
{"identifier":"Q25105040","url":"https://www.wikidata.org/entity/Q25105040"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/f/f2/ABT-737.svg","width":1517,"height":587}
fields total:
13
integrity:
16