7-Chlorokynurenic acid
id:
7-chlorokynurenic-acid-184-272615
title:
7-Chlorokynurenic acid
text:
7-Chlorokynurenic acid (7-CKA) is a tool compound that acts as a potent and selective competitive antagonist of the glycine site of the NMDA receptor. It produces ketamine-like rapid antidepressant effects in animal models of depression. However, 7-CKA is unable to cross the blood-brain-barrier, and for this reason, is unsuitable for clinical use. As a result, a centrally-penetrant prodrug of 7-CKA, 4-chlorokynurenine (AV-101), has been developed for use in humans, and is being studied in clinic
brand slug:
wiki
category slug:
encyclopedia
description:
Chemical compound
original url:
https://en.wikipedia.org/wiki/7-Chlorokynurenic_acid
date created:
2013-11-13T04:29:57Z
date modified:
2024-09-07T00:58:17Z
main entity:
{"identifier":"Q15634175","url":"https://www.wikidata.org/entity/Q15634175"}
image:
{"content_url":"https://upload.wikimedia.org/wikipedia/commons/2/2c/7-Chlorokynurenic_acid.svg","width":520,"height":350}
fields total:
13
integrity:
16